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Methoxetamine is yet another drug from the designer stable.

What is it?

Commonly known as MXE or mexxy by its users, this dissociative anaesthetic is chemically similar to ketamine and PCP. It has been touted as a ketamine-substitute, but many feel it is far stronger than that.

Origins of the drug vary, but a common explanation is that it was originally synthesized by an underground chemist for treating those in chronic pain.

Positive short-term effects:

Those in favour of this drug report the following positive effects:

  • Mild euphoria. Users describe this as a warmth.
  • Increased stimulation. Enlightenment is a word often used to describe this sensation.
  • Hallucinogenic experiences. Seeing and hearing things that are not actually present.
  • Sense of time becomes unimportant.
  • Extra energy. This varies on the amount taken and how the user takes to the drug, but ranges from a mild increase in energy to almost limitless.
  • Lowered inhibitions

Negative short-term effects:

Users have reported various side effects. These include:

  • Dizziness
  • Dissociative effects
  • Double vision
  • Impaired coordination
  • Disorientation
  • Confusion
  • Nauseous feelings
  • Unconsciousness

4 negative aspects deserve a ‘special’ mention:

Dissociative effects:

Users often comment that the drug makes them feel as if their mind and body have separated. An even more severe form of dissociation has also been reported. This is known as catatonia.

This condition means that although a person is awake they are unable to respond to or interact with anything at all.


The strength of the drug means that only a small amount is required to have a substantial effect. This fact also makes it far easier to accidentally overdose.

Heart beat:

The drug can make the heart beat faster than normal. This condition is known as tachycardia. It also increases blood pressure. Both symptoms can be pre-cursors to strokes and heart attacks.

Double trouble:

If the drug puts a user in a dissociative state and they are also hallucinating there is a possibility of higher than normal risks being taken. These increased risks can lead to injury for the user and those closest to them.

The long-term effects:

Those who use the drug on a regular or heavy basis need to be aware that far more research on it needs to be completed. This means that the long-term effects of use are not yet known.

As mentioned, it is marketed as a replacement for ketamine. It supposedly gives similar feelings without the harmful effect ketamine has on the bladder.

Ketamine users are subject to very serious bladder problems that cause severe pain and make it difficult to pass urine. In extreme cases, the condition leads to removal of the bladder.

This ketamine related condition has only been discovered after many years of use.

Methoxetamine was introduced to the market in 2010. In terms of medication it is a relative newcomer. There is no evidence to say that over time and with prolonged use that this drug will not turn out to be just as toxically harmful to a user’s bladder as ketamine is.

Regular use may be a regret:

The potentially unknown long-term effects repeated use could cause may well negatively affect a user’s health in later life. Is that worth the risk for the effects received now?

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